Linked Life Data

2842716

Source:http://linkedlifedata.com/resource/pubmed/id/2842716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-10-13
pubmed:abstractText
We have studied SV40 gene expression during transforming infection of Go-arrested primary mouse kidney cell cultures. The results show that both early and late viral genes are simultaneously expressed during a short restricted period of time. Synthesis of T-antigen is also time limited and precedes the first SV40-induced cellular DNA replication and mitosis. Cells in mitosis retained stable T-antigen which was redistributed and transmitted to daughter nuclei. Even though no reinitiation of viral transcription occurred after the first mitosis, several cycles of cellular DNA synthesis and mitosis was observed. These results suggest that over a several day period, stable T-antigen conferred a continuous mitotic stimulus to the infected cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-200
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
One single burst of SV40 gene expression induces cell proliferation in transforming infection of mouse cells.
pubmed:affiliation
Department of Molecular Biology, Geneva, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't