Linked Life Data

2835702

Source:http://linkedlifedata.com/resource/pubmed/id/2835702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-6-10
pubmed:abstractText
Vasoactive intestinal peptide (VIP) elevates the levels of cyclic AMP in primary cultures of highly purified chromaffin cells isolated from the bovine adrenal medulla, an effect that is potentiated by inhibitors of cyclic nucleotide phosphodiesterases. This elevation occurs within minutes and elevated levels of cyclic AMP are observed for as long as 24 hr in culture. The half-maximally effective concentration of VIP was approximately 1 microM. The VIP-induced elevation in chromaffin cell cyclic AMP levels was potentiated by simultaneous addition of secretagogues which alone also elevated cellular cyclic AMP levels. VIP alone failed to evoke catecholamine secretion from chromaffin cells, but potentiated potassium-, veratridine-, and nicotine-evoked secretion. Because VIP is found in nerve terminals innervating the adrenal medulla, this neuropeptide appears to be a modulator of chromaffin cell function, possibly via regulation of cyclic AMP levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0143-4179
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Vasoactive intestinal peptide elevates cyclic AMP levels and potentiates secretion in bovine adrenal chromaffin cells.
pubmed:affiliation
Department of Pharmacology, University of South Carolina School of Medicine, Columbia 29208.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S.