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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-6-1
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pubmed:abstractText |
Vaccination of guinea pigs with recombinant glycoprotein D (subunit vaccine) from either herpes simplex virus type 1 or type 2 (HSV-1, HSV-2), before intravaginal inoculation with HSV-2, markedly altered viral replication in the vaginal tract and reduced, or completely prevented, the development and spread of external genital lesions. Vaccination with glycoprotein D from HSV-2 prevented the establishment of latent HSV-2 infections in dorsal root ganglia and reduced the frequency of recurrent episodes. For all parameters of efficacy that we tested, vaccination with glycoprotein D from HSV-2 was more effective than was vaccination with protein derived from HSV-1. Vaccination after primary infection had no effect on the frequency or duration of recurrent HSV-2 infections.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1899
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
897-902
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2834467-Animals,
pubmed-meshheading:2834467-Antigens,
pubmed-meshheading:2834467-Female,
pubmed-meshheading:2834467-Ganglia, Spinal,
pubmed-meshheading:2834467-Guinea Pigs,
pubmed-meshheading:2834467-Herpes Genitalis,
pubmed-meshheading:2834467-Recurrence,
pubmed-meshheading:2834467-Simplexvirus,
pubmed-meshheading:2834467-Vaccination,
pubmed-meshheading:2834467-Vaccines, Synthetic,
pubmed-meshheading:2834467-Viral Envelope Proteins,
pubmed-meshheading:2834467-Viral Vaccines
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pubmed:year |
1988
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|
pubmed:articleTitle |
Efficacy of recombinant glycoprotein D subunit vaccines on the development of primary, recurrent, and latent genital infections with herpes simplex virus type 2 in guinea pigs.
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pubmed:affiliation |
Department of Molecular Biology, Genentech, Incorporated, South San Francisco, California 94080.
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pubmed:publicationType |
Journal Article
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