Linked Life Data

2830578

Source:http://linkedlifedata.com/resource/pubmed/id/2830578

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-3-30
pubmed:abstractText
We have introduced 3'-terminal deletions of increasing size in the v-erbB oncogene and analysed the effects of these mutations on the transformation of fibroblasts and erythroblasts. The results show that the transforming activity of the mutants is gradually diminished, and completely abolished in those mutants that do not produce stable v-erbB proteins. The capacity to transform erythroblasts is lost before fibroblast transformation is severely affected, suggesting that a larger part of the C-terminal domain is required for mitogenic signalling in erythroid cells than in fibroblasts. In addition, the v-erbA oncogene was found to cooperate with v-erbB not only in erythroblast but also in fibroblast transformation, inducing a fully transformed phenotype in fibroblasts partially transformed by a mutant erbB oncogene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Defective v-erbB genes can be complemented by v-erbA in erythroblast and fibroblast transformation.
pubmed:affiliation
Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, GFR.
pubmed:publicationType
Journal Article