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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-2-29
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pubmed:abstractText |
A study of 2-deoxyglucose transport into polymorphonuclear leukocytes (PMN) was performed in three patients with glycogen storage disease (GSD) type Ib. The rate of 2-deoxyglucose transport into GSD Ib PMN was 30% of that of cells of normal controls. In GSD Ib lymphocytes, transport was normal. Km for 2-deoxyglucose in the PMN of one patient was within the normal range. The reduced transport was not due to the elevation in Km for 2-deoxyglucose nor to the decreased rate of phosphorylation of 2-deoxyglucose. The striking limitation of glucose transport across the cell membrane may account for the impairment of leukocyte function which is characteristic of GSD Ib.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0141-8955
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-41
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pubmed:dateRevised |
2007-3-21
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pubmed:meshHeading |
pubmed-meshheading:2828761-Antiporters,
pubmed-meshheading:2828761-Biological Transport,
pubmed-meshheading:2828761-Deoxy Sugars,
pubmed-meshheading:2828761-Deoxyglucose,
pubmed-meshheading:2828761-Glycogen Storage Disease,
pubmed-meshheading:2828761-Humans,
pubmed-meshheading:2828761-Kinetics,
pubmed-meshheading:2828761-Monosaccharide Transport Proteins,
pubmed-meshheading:2828761-Neutrophils,
pubmed-meshheading:2828761-Phosphorylation,
pubmed-meshheading:2828761-Phosphotransferases
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pubmed:year |
1987
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pubmed:articleTitle |
Impaired glucose transport in polymorphonuclear leukocytes in glycogen storage disease Ib.
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pubmed:affiliation |
Pediatric Research Laboratory, Soroka Medical Center, Beer Sheva, Israel.
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pubmed:publicationType |
Journal Article
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