Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0005795,
umls-concept:C0019169,
umls-concept:C0019189,
umls-concept:C0020202,
umls-concept:C0021311,
umls-concept:C0030705,
umls-concept:C0033105,
umls-concept:C0034580,
umls-concept:C0205345,
umls-concept:C0229671,
umls-concept:C0336791,
umls-concept:C0348026,
umls-concept:C0687725,
umls-concept:C2239176
|
| pubmed:issue |
6
|
| pubmed:dateCreated |
1988-3-18
|
| pubmed:abstractText |
Anti-HBs monoclonal antibodies radioimmunoassay (m-RIA) and HBV-DNA hybridization techniques were used to detect HBs antigen (HBsAg)--associated determinants (evidence of HBV on-going infection) and HBV-DNA sequences (evidence of viral multiplication) in the serum samples of 479 patients who were HBsAg negative by standard solid-phase radioimmunoassay. They included 128 alcoholics, 104 patients with chronic hepatitis, fifty-four with an hepatocellular carcinoma, 100 with coagulation disorders and ninety-three blood donors. The aim of this study was the comparison in these populations of the prevalence of the various HBV markers. m-RIA detected HBsAg-associated determinants in 1% of blood donors, 3% of coagulation disorders, 3.1% of the alcoholics, 21.1% of chronic hepatitis and 16.6% of hepatocellular carcinoma; hybridization identified HBV-DNA sequences in 0.9%, 2.2%, 10.9%, 9.6% and 5.5% of these cases, respectively. The combined prevalence of both markers of an on-going HBV infection (with or without viral multiplication) was 14.16%, 26.9% and 22.2% in the latter groups, respectively, as compared with only 3% in patients with coagulation disorders and 2.1% of blood donors. These results confirm the frequency of HBV or HBV-related virus infection in alcoholics, in chronic hepatitis and hepatocellular carcinomas, despite the absence of HBsAg by standard RIA (or even of any other usual marker); this gives further evidence for variations in the expression of HBV infection. A high and quite similar prevalence of usual serum markers and hybridization results was observed in the alcoholics and in the patients with chronic hepatitis.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0014-2972
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
515-21
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2828076-Adult,
pubmed-meshheading:2828076-Aged,
pubmed-meshheading:2828076-Alcoholism,
pubmed-meshheading:2828076-Antibodies, Monoclonal,
pubmed-meshheading:2828076-Blood Donors,
pubmed-meshheading:2828076-Carcinoma, Hepatocellular,
pubmed-meshheading:2828076-Chronic Disease,
pubmed-meshheading:2828076-DNA, Viral,
pubmed-meshheading:2828076-Female,
pubmed-meshheading:2828076-Hepatitis,
pubmed-meshheading:2828076-Hepatitis B,
pubmed-meshheading:2828076-Hepatitis B Antibodies,
pubmed-meshheading:2828076-Hepatitis B Surface Antigens,
pubmed-meshheading:2828076-Hepatitis B virus,
pubmed-meshheading:2828076-Humans,
pubmed-meshheading:2828076-Liver Neoplasms,
pubmed-meshheading:2828076-Male,
pubmed-meshheading:2828076-Middle Aged,
pubmed-meshheading:2828076-Nucleic Acid Hybridization,
pubmed-meshheading:2828076-Radioimmunoassay
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Monoclonal anti-HBs antibodies radioimmunoassay and serum HBV-DNA hybridization as diagnostic tools of HBV infection: relative prevalence among HBsAg-negative alcoholics, patients with chronic hepatitis or hepatocellular carcinomas and blood donors.
|
| pubmed:affiliation |
Unité d'Hépatologie--INSERM U-99, Hôpital Laënnec, Paris, France.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|