Linked Life Data

2826647

Source:http://linkedlifedata.com/resource/pubmed/id/2826647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-2-3
pubmed:abstractText
Three variants of herpes simplex virus type 1 strain 17 were isolated. One variant had a deletion of 2.5 X 10(6) Mr in IRL/UL and 0.8 X 10(6) Mr in TRL such that sequences were deleted from both long repeats. The deletion in UL removed the 20K and 22K open reading frames. The second variant had a deletion of 3.5 X 10(6) Mr in IRL/UL which again removed the 20K and 22K open reading frames. The third variant had a similar deletion in UL, but in this case the deleted sequences were replaced by sequences from the left end of UL, such that the long repeat was extended by 3 X 10(6) Mr and the overall genome size by 2 X 10(6) Mr. All three variants grew almost normally in vitro. The analysis of 11 isolates with extensive variation in the long repeats outside the 'a' sequence is also reported.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
68 ( Pt 12)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3019-31
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Deletion and duplication variants around the long repeats of herpes simplex virus type 1 strain 17.
pubmed:affiliation
MRC Virology Unit, University of Glasgow, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't