Linked Life Data

2824144

Source:http://linkedlifedata.com/resource/pubmed/id/2824144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-1-15
pubmed:abstractText
Regional development of beta-adrenergic binding sites in the rat fetal central nervous system and pineal gland were studied in relation to the ontogeny of different drug and neurotransmitter binding sites. 3H-dihydroalprenolol labels the olfactory bulb very early in fetal life. A comparatively early development of binding sites is also seen for benzodiazepines during late gestation. 3H-serotonin, 3H-muscimol, 3H-GABA and 3H-(N)-methylscopolamine additionally label the olfactory bulb, revealing quite different patterns. Around gestational day 16, beta-adrenergic sites were found in the neocortex, then in choroid plexus and in the pineal gland. Besides beta-adrenergic, only 3H-flunitrazepam binding sites are detectable in the fetal eye, the latter with a more restricted regional distribution. In the fetal pineal, beta-adrenergic, muscarinic cholinergic and serotonergic binding sites appear at different times in gestation. In the neocortex a variety of binding site patterns develop. Two more general types can be distinguished: appearance along with caudorostral maturation of the brain and appearance within distinct brain regions, possibly related to local differentiation processes. The simultaneous onset of various binding sites in distinct areas of the fetal brain might result in higher sensitivity of individual brain areas to drugs.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-8305
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
422-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Beta-adrenergic binding sites in fetal rat central nervous system and pineal gland: their relation to other receptor sites.
pubmed:affiliation
Institute of Pharmacology, University of Zürich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't