| pubmed-article:2824088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2824088 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:2824088 | lifeskim:mentions | umls-concept:C0220641 | lld:lifeskim |
| pubmed-article:2824088 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:2824088 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2824088 | pubmed:dateCreated | 1988-1-5 | lld:pubmed |
| pubmed-article:2824088 | pubmed:abstractText | The hamster cheek pouch is an excellent model for the experimental induction of oral tumor by chemical carcinogens. We have previously shown that the cellular oncogene c-erb B1 is overexpressed in the cheek pouch of the Syrian hamster when transformed by the carcinogenic chemical dimethyl-benzanthracene (DMBA). Here we report that this cellular oncogene is amplified in one such chemically-induced oral carcinoma (HCP-T12) and in a cell line (HCPC-1) established from a similarly derived tumor. Furthermore we present preliminary evidence that the gene amplification is most likely through an extrachromosomal pathway. These data together suggest that the amplification of the c-erb B1 oncogene might be responsible for its overexpression in these chemically-induced oral carcinomas. | lld:pubmed |
| pubmed-article:2824088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2824088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2824088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2824088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2824088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2824088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2824088 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2824088 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:2824088 | pubmed:author | pubmed-author:WongD TDT | lld:pubmed |
| pubmed-article:2824088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2824088 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:2824088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2824088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2824088 | pubmed:pagination | 1963-5 | lld:pubmed |
| pubmed-article:2824088 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:meshHeading | pubmed-meshheading:2824088-... | lld:pubmed |
| pubmed-article:2824088 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2824088 | pubmed:articleTitle | Amplification of the c-erb B1 oncogene in chemically-induced oral carcinomas. | lld:pubmed |
| pubmed-article:2824088 | pubmed:affiliation | Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, MA 02115. | lld:pubmed |
| pubmed-article:2824088 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2824088 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2824088 | lld:pubmed |
