Linked Life Data

2824088

Source:http://linkedlifedata.com/resource/pubmed/id/2824088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1988-1-5
pubmed:abstractText
The hamster cheek pouch is an excellent model for the experimental induction of oral tumor by chemical carcinogens. We have previously shown that the cellular oncogene c-erb B1 is overexpressed in the cheek pouch of the Syrian hamster when transformed by the carcinogenic chemical dimethyl-benzanthracene (DMBA). Here we report that this cellular oncogene is amplified in one such chemically-induced oral carcinoma (HCP-T12) and in a cell line (HCPC-1) established from a similarly derived tumor. Furthermore we present preliminary evidence that the gene amplification is most likely through an extrachromosomal pathway. These data together suggest that the amplification of the c-erb B1 oncogene might be responsible for its overexpression in these chemically-induced oral carcinomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1963-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Amplification of the c-erb B1 oncogene in chemically-induced oral carcinomas.
pubmed:affiliation
Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, MA 02115.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't