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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1987-11-13
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pubmed:databankReference | |
pubmed:abstractText |
The 2300 base-pair transposon-like human element, THE-1, has been identified in the extrachromosomal circular DNA of the established human cell line HeLa as a relatively homogeneous population of covalently closed 1900 base-pair molecules. THE-1, which has been classified tentatively as a retroviral-like transposable element (a retrotransposon), is present in the extrachromosomal circular DNA of African green monkey (BSC-1) and human lymphoblastoid (Jurkat) cell lines. The 1900 base-pair extrachromosomal elements isolated and cloned from HeLa cells (1) appear to contain only THE-1-specific nucleotide sequences, (2) are circularized versions of the linear chromosomal sequence, and (3) are related predominantly to a single, or single type of, family member.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2821286-Autoradiography,
pubmed-meshheading:2821286-Base Sequence,
pubmed-meshheading:2821286-Cloning, Molecular,
pubmed-meshheading:2821286-DNA, Circular,
pubmed-meshheading:2821286-DNA Transposable Elements,
pubmed-meshheading:2821286-Extrachromosomal Inheritance,
pubmed-meshheading:2821286-HeLa Cells,
pubmed-meshheading:2821286-Humans,
pubmed-meshheading:2821286-Molecular Sequence Data
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pubmed:year |
1987
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pubmed:articleTitle |
Cloned extrachromosomal circular DNA copies of the human transposable element THE-1 are related predominantly to a single type of family member.
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pubmed:affiliation |
Department of Biochemistry, New York University School of Medicine, NY 10016.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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