Linked Life Data

2816873

Source:http://linkedlifedata.com/resource/pubmed/id/2816873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1989-12-12
pubmed:abstractText
Several products of arachidonic acid metabolism were assayed in whole saliva of patients with cystic fibrosis, a disease affecting primarily the exocrine glands. The levels of prostaglandins (PG) E2 and F2 alpha were elevated fourfold in patients with cystic fibrosis, compared with a control group (mean +/- SEM for PGE2 1.13 +/- 0.22 vs 0.37 +/- 0.08 ng/ml saliva, p less than 0.005; and for PGE2 alpha 0.84 +/- 0.27 vs 0.17 +/- 0.03 ng/ml saliva, p less than 0.025). The levels of PGI2, hydroxyeicosatetraenoic acids, and leukotrienes showed no significant differences between the two groups. These changes were not present in individuals heterozygous for the cystic fibrosis gene. Study of appropriate control groups suggested that the changes that we observed in patients with cystic fibrosis could not be attributed to their lung disease or to the medications these patients were receiving. Our findings indicate that metabolism of arachidonic acid is abnormal in cystic fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9270
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1408-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Prostaglandins E2 and E2 alpha are elevated in saliva of cystic fibrosis patients.
pubmed:affiliation
Department of Biochemistry, Brandeis University, Waltham, Massachusetts.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't