Linked Life Data

2811712

Source:http://linkedlifedata.com/resource/pubmed/id/2811712

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-12-19
pubmed:abstractText
In summary the Key Theory states that certain planar molecules can act in latching together enhancer elements with promoter elements to create hypersensitive recognition for super-efficient initiation sites of RNA polymerase activity of a specific structural gene. Specificities of these key molecules are required because of transacting factor binding and minor groove steric relationships and/or alkylations that in turn forms relatively permanent "on" modes of gene activity. This presents an explanation for the mechanism of a great variety of biologically active molecules such as steroid hormones and carcinogens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXII. Key theory--a mechanism for enhancer function.
pubmed:affiliation
Departmento de Investigación Cientifica de la Facultad de Medicina Teórica, Universidad Autónama de Tamaulipas, México.
pubmed:publicationType
Journal Article