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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-12-5
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pubmed:abstractText |
Monocyte-depleted mononuclear cells (MNC) from healthy subjects synthesized IgM-class antibody to single-stranded DNA (anti-ssDNA) at significantly higher levels than unfractionated MNC. The increased production of IgM anti-ssDNA by monocyte-depleted normal MNC was inhibited to a greater degree than total IgM by addition of supernatants from autologous monocytes. Moreover, supernatants obtained from normal monocytes cultured with indomethacin retained this suppressive effect on IgM anti-ssDNA antibody production, suggesting that prostaglandin E2 may not be involved in the suppression. These results indicate that B cells programmed to produce IgM anti-ssDNA are present in the normal B cell repertoire, but may be suppressed by monocytes or by a soluble factor (or factors) from the monocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-2580537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-2582059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-2974766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-308952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-315849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-3304299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-3338192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-3493867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-409950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-4202376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6186739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6211307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6307568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6347489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6452238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6965452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2805410-6983913
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Monocyte-mediated suppression of anti-DNA antibody production in healthy subjects.
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pubmed:affiliation |
Division of Immunology, National Medical Center, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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