Linked Life Data

280155

Source:http://linkedlifedata.com/resource/pubmed/id/280155

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1978-12-27
pubmed:abstractText
The antiviral effect of 9-MS was examined in mice infected with mouse-adapted influenza A2 (H2N2) virus. Either a single or a continuous prophylactic administration of 9-MS protected mice from virus infection, and comparison of the minimal effective dose with the lethal dose gave a therapeutic index of approximately 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. A potent virus-inhibitory factor was detected in the lung and serum after a single intraperitoneal administration of 9-MS in uninfected mice, and on the basis of chemical characteristics of this inhibitory factor, it was assumed to be an interferon. These results suggest that the protective activity of the antibiotic in mice is due to interferon induction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
284
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-75
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Effect of an interferon inducer, 9-methylstreptimidone, on influenza virus infection in mice.
pubmed:publicationType
Journal Article