Linked Life Data

2794849

Source:http://linkedlifedata.com/resource/pubmed/id/2794849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-11-17
pubmed:abstractText
The sulphur amino acids methionine, cysteine (1/2-cystine) and taurine were determined by ion-exchange chromatography in plasma and muscle biopsy material obtained from 46 patients with chronic renal failure. Twelve patients were untreated, eight patients were treated with a low protein diet supplemented with essential amino acids, 11 patients treated with maintenance haemodialysis and 15 patients with continuous ambulatory peritoneal dialysis (CAPD). Patient data were compared to data obtained from 18 healthy subjects. Plasma cysteine was elevated in the untreated patients, in the patients treated with low protein diet and in the maintenance haemodialysis patients. Muscle methionine was significantly elevated in the CAPD patients. Plasma taurine was decreased in the untreated patients and in the CAPD patients and muscle taurine was borderline low in the untreated patients and significantly decreased in the other patient groups. The results show that taurine depletion may occur in patients with chronic uraemia despite normal or elevated concentrations of precursor sulphur amino acids, suggesting inhibited synthesis or enhanced degradation of taurine in the uraemic state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0954-6820
pubmed:author
pubmed:issnType
Print
pubmed:volume
226
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-94
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Sulphur amino acids in plasma and muscle in patients with chronic renal failure: evidence for taurine depletion.
pubmed:affiliation
Department of Renal Medicine, Karolinska Institute, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't