Linked Life Data

2790536

Source:http://linkedlifedata.com/resource/pubmed/id/2790536

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-11-7
pubmed:abstractText
We have utilized [3H]diacetyl-didemnin B ([3H]DB) in a series of in vitro experiments to determine the time course of equilibration of [3H]DB between plasma and blood cells, the distribution of [3H]DB among blood cells, and the distribution of [3H]DB in plasma. Within 45-60 min at 37 degrees C, approximately 55% of [3H]DB added to whole blood remained in the plasma. Of the drug associated with blood cells, 77% was found with the red blood cells, 18% with the lymphocytes, and 5% with the granulocytes. However, on the basis of amount of drug uptake per cell, lymphocytes incorporated nearly 400 times more and granulocytes nearly 30 times more [3H]DB than red blood cells. No specific association of [3H]DB with a particular lymphocyte subset was detected. Additionally, it appears that [3H]DB in plasma was associated to a large extent with albumin.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0735-7907
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
In vitro distribution of diacetyl didemnin B in human blood cells and plasma.
pubmed:affiliation
Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S.