|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1989-9-15
|
|
pubmed:abstractText |
Enhancement of HIV-I production by immunostimulators leakadine (5 micrograms/ml) and thymosin (10 micrograms/ml) by 40 +/- 10% and a significant inhibition of HIV-I production by immunosuppressors cortisone and dexasone was demonstrated in H9 culture. HIV-I production was estimated by the number of cells expressing viral antigens on the membranes. The effect of modulation by immunocorrective agents of H9 cell sensitivity to HIV-I was found not to be associated with the effect of the drugs on CD4-receptor expression. A relationship between the immunostimulating doses of the drug and the concentration in which it enhances virus production was demonstrated. Possible mechanisms of the phenomenon are discussed.
|
|
pubmed:language |
rus
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0507-4088
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
34
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
171-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2788329-Adjuvants, Immunologic,
pubmed-meshheading:2788329-Animals,
pubmed-meshheading:2788329-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2788329-HIV Antigens,
pubmed-meshheading:2788329-HIV-1,
pubmed-meshheading:2788329-Humans,
pubmed-meshheading:2788329-Immunosuppressive Agents,
pubmed-meshheading:2788329-Lymphocyte Activation,
pubmed-meshheading:2788329-Mice,
pubmed-meshheading:2788329-Mice, Inbred C57BL,
pubmed-meshheading:2788329-Mitogens,
pubmed-meshheading:2788329-Virus Cultivation,
pubmed-meshheading:2788329-Virus Replication
|
|
pubmed:articleTitle |
[Effect of immunocorrective agents on the production of the human immunodeficiency virus type 1 in vitro].
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|
