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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4915
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pubmed:dateCreated |
1989-8-18
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pubmed:abstractText |
When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
245
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
308-10
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:2787531-Animals,
pubmed-meshheading:2787531-Antibodies, Monoclonal,
pubmed-meshheading:2787531-Eosinophilia,
pubmed-meshheading:2787531-Immunoglobulin E,
pubmed-meshheading:2787531-Interleukin-4,
pubmed-meshheading:2787531-Interleukin-5,
pubmed-meshheading:2787531-Interleukins,
pubmed-meshheading:2787531-Mice,
pubmed-meshheading:2787531-Mice, Inbred BALB C,
pubmed-meshheading:2787531-Nematode Infections,
pubmed-meshheading:2787531-Nippostrongylus
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pubmed:year |
1989
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pubmed:articleTitle |
Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice.
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pubmed:affiliation |
DNAX Research Institute, Palo Alto, CA 94304.
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pubmed:publicationType |
Journal Article
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