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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1989-7-18
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pubmed:abstractText |
The in-vitro activity of a new penem FCE 22101 was evaluated in comparison with other antimicrobial agents against 966 aerobic and anaerobic Gram-negative and Gram-positive bacteria. FCE 22101 inhibited 90% of Enterobacteriaceae, Haemophilus influenzae, H. parainfluenzae, H. ducreyi, Neisseria gonorrhoeae, Branhamella catarrhalis, Staphylococcus aureus, Staph. epidermidis and group B streptococcus at concentrations of 0.12-4.0 mg/l. Pseudomonas aeruginosa was resistant with MIC90 of greater than 32 mg/l. Streptococcus faecalis displayed MIC90 of 16 mg/l. Bacteroides fragilis, Clostridium spp., Peptococcus spp. and Peptostreptococcus spp. were inhibited at concentrations of 0.25-2.0 mg/l. beta-Lactamase-producing or methicillin resistant bacteria did not have significantly elevated MICs. FCE 22101 was generally less active than imipenem but more active than other beta-lactam antibiotics examined.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carbapenems,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Lactamases,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Lactams,
http://linkedlifedata.com/resource/pubmed/chemical/ritipenem
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0305-7453
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23 Suppl C
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2786518-Anti-Bacterial Agents,
pubmed-meshheading:2786518-Bacteria,
pubmed-meshheading:2786518-Bacterial Infections,
pubmed-meshheading:2786518-Carbapenems,
pubmed-meshheading:2786518-Gram-Negative Bacteria,
pubmed-meshheading:2786518-Gram-Positive Bacteria,
pubmed-meshheading:2786518-Microbial Sensitivity Tests,
pubmed-meshheading:2786518-beta-Lactamases,
pubmed-meshheading:2786518-beta-Lactams
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pubmed:year |
1989
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pubmed:articleTitle |
In-vitro activity of a new penem FCE 22101.
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pubmed:affiliation |
Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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