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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0017337,
umls-concept:C0079411,
umls-concept:C0086418,
umls-concept:C0330390,
umls-concept:C0337112,
umls-concept:C0376315,
umls-concept:C0597357,
umls-concept:C1173313,
umls-concept:C1522642,
umls-concept:C1524075,
umls-concept:C2003941
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pubmed:issue |
4904
|
|
pubmed:dateCreated |
1989-6-20
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pubmed:databankReference |
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pubmed:abstractText |
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain. The cDNA encoding the human IL-2R beta chain has now been isolated. The overall primary structure of the IL-2R beta chain shows no apparent homology to other known receptors. Unlike the IL-2R alpha chain, the IL-2R beta chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied. The cDNA-encoded beta chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells. Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
551-6
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:2785715-Amino Acid Sequence,
pubmed-meshheading:2785715-Base Sequence,
pubmed-meshheading:2785715-Cloning, Molecular,
pubmed-meshheading:2785715-Cross-Linking Reagents,
pubmed-meshheading:2785715-DNA,
pubmed-meshheading:2785715-Fibroblasts,
pubmed-meshheading:2785715-Gene Expression Regulation,
pubmed-meshheading:2785715-Humans,
pubmed-meshheading:2785715-Interleukin-2,
pubmed-meshheading:2785715-Leukemia,
pubmed-meshheading:2785715-Molecular Sequence Data,
pubmed-meshheading:2785715-Nucleic Acid Hybridization,
pubmed-meshheading:2785715-RNA, Messenger,
pubmed-meshheading:2785715-Receptors, Interleukin-2,
pubmed-meshheading:2785715-Recombinant Proteins,
pubmed-meshheading:2785715-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2785715-Signal Transduction,
pubmed-meshheading:2785715-Succinimides,
pubmed-meshheading:2785715-T-Lymphocytes,
pubmed-meshheading:2785715-Transfection,
pubmed-meshheading:2785715-Tumor Cells, Cultured
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pubmed:year |
1989
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pubmed:articleTitle |
Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
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pubmed:affiliation |
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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