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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-4-19
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pubmed:abstractText |
A potential mechanism is described by which a growth factor may prevent the action of antiestrogens or reactive the growth of hormone-responsive breast carcinoma in patients undergoing tamoxifen (TAM) treatment. Epidermal growth factor (EGF)-stimulated growth (10(-8) M EGF) was assayed in the MCF-7 breast cancer cell line in the presence of various concentrations (10(-10) to 10(-6) M) of three antiestrogens, 4-hydroxytamoxifen (OH TAM), TAM and ICI 164384. In each case, the EGF-stimulated increases in DNA were not inhibited by the antiestrogen. OH TAM and ICI 164384 inhibited estradiol (E2) stimulated cell proliferation in a dose-related fashion. However, in the presence of both E2 and EGF, these two antiestrogens inhibited E2 effects only; EGF promotion of growth was unaffected. Pretreatment of MCF-7 cells for 2 days with either OH TAM or ICI 164384 did not inhibit EGF-induced increases in cell proliferation. We propose that eventual antiestrogen therapeutic failure may be caused by the paracrine influences of growth factors from neighboring cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0277-5379
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-63
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2784101-Breast Neoplasms,
pubmed-meshheading:2784101-Cell Line,
pubmed-meshheading:2784101-DNA, Neoplasm,
pubmed-meshheading:2784101-Dose-Response Relationship, Drug,
pubmed-meshheading:2784101-Epidermal Growth Factor,
pubmed-meshheading:2784101-Estradiol,
pubmed-meshheading:2784101-Estradiol Antagonists,
pubmed-meshheading:2784101-Estrogen Antagonists,
pubmed-meshheading:2784101-Female,
pubmed-meshheading:2784101-Humans,
pubmed-meshheading:2784101-Mitosis,
pubmed-meshheading:2784101-Polyunsaturated Alkamides,
pubmed-meshheading:2784101-Tamoxifen,
pubmed-meshheading:2784101-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
Contrasting ability of antiestrogens to inhibit MCF-7 growth stimulated by estradiol or epidermal growth factor.
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pubmed:affiliation |
Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison 53792.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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