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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-2-23
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pubmed:abstractText |
Interleukin 1 has been implicated as a mediator of both systemic and local responses to infection and injury. Since systemic and local vasodilatation are hallmarks of sepsis and infection, we studied the direct effect of IL-1 on vascular contractility. We report here that human recombinant IL-1-beta potently inhibits the response of rat thoracic aorta to vasoconstrictor agents. Exposure of isolated rat aortic rings to IL-1 (20 ng/ml) for 1 h did not affect phenylephrine-induced contractions during the exposure period. However, when rings were retested 150-200 min after initiation of IL-1 exposure, contractions were markedly decreased. The cytokine had a similar effect in rings from which the endothelium was removed. Contractions caused by potassium depolarization also were depressed, indicating the effect of IL-1 is not specific to the alpha-adrenoceptor agonist. The inhibitory effect of IL-1 was concentration-dependent (0.2 to 20 ng/ml), and eliminated by pretreatment with cycloheximide (20 micrograms/ml). Indomethacin (10(-5) M) did not prevent the inhibition caused by IL-1. These studies identify IL-1 as a potent inhibitor of vascular contraction, via an endothelium-independent mechanism. Studies with inhibitors suggest that the action of IL-1 is independent of prostanoid synthesis, and may involve synthesis of protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-2409598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-2416819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-2835680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-2872233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3009791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3107241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3258319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3276731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3390663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3491091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3519678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3526909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-3871441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-6253831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2783426-6332168
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2783426-Animals,
pubmed-meshheading:2783426-Cycloheximide,
pubmed-meshheading:2783426-Indomethacin,
pubmed-meshheading:2783426-Interleukin-1,
pubmed-meshheading:2783426-Male,
pubmed-meshheading:2783426-Muscle, Smooth, Vascular,
pubmed-meshheading:2783426-Muscle Contraction,
pubmed-meshheading:2783426-Phenylephrine,
pubmed-meshheading:2783426-Rats,
pubmed-meshheading:2783426-Rats, Inbred Strains,
pubmed-meshheading:2783426-Recombinant Proteins,
pubmed-meshheading:2783426-Vasoconstriction
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pubmed:year |
1989
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pubmed:articleTitle |
Interleukin 1 inhibits contraction of vascular smooth muscle.
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pubmed:affiliation |
Evans Memorial Department of Clinical Research, University Hospital at Boston University Medical Center, Massachusetts 02118.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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