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pubmed-article:2774708pubmed:abstractTextWe have recently reported the rapid appearance of bacteria and endotoxin in the blood of rats and of trauma patients in the course of 30 minutes to 2 hours of hemorrhagic shock. The current study was designed to determine the effect of this bacteremia and endotoxemia on survival. Thirty-three conventional (C:group 1) and 36 germ-free (GF:group 2) Sprague Dawley rats were subjected to our previously described model of treated hemorrhagic shock. Survival in the GF group was significantly better than the C group at 24, 48, and 72 hours after shock. Endotoxin levels were elevated in 88% of C group during shock and in 28% of GF group. The gut of the GF animal contains endotoxin (26 ng/gm of stool) as does the sterile food supply (393 ng/gm of rat chow).lld:pubmed
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pubmed-article:2774708pubmed:articleTitleDoes the bacteremia observed in hemorrhagic shock have clinical significance? A study in germ-free animals.lld:pubmed
pubmed-article:2774708pubmed:affiliationDepartment of Surgery, New Jersey Medical School, Newark 07103.lld:pubmed
pubmed-article:2774708pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2774708pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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