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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-10-6
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pubmed:abstractText |
We have recently reported the rapid appearance of bacteria and endotoxin in the blood of rats and of trauma patients in the course of 30 minutes to 2 hours of hemorrhagic shock. The current study was designed to determine the effect of this bacteremia and endotoxemia on survival. Thirty-three conventional (C:group 1) and 36 germ-free (GF:group 2) Sprague Dawley rats were subjected to our previously described model of treated hemorrhagic shock. Survival in the GF group was significantly better than the C group at 24, 48, and 72 hours after shock. Endotoxin levels were elevated in 88% of C group during shock and in 28% of GF group. The gut of the GF animal contains endotoxin (26 ng/gm of stool) as does the sterile food supply (393 ng/gm of rat chow).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-13513911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-13575544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-13749226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-13847964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-14490657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-2918713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-2950241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-2953938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3019260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3055397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3113398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3140765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3178484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3195849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3276906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3277470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3294427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3377565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3488050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3545142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3588631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3592811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-3961653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-4605257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-4862208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-6456996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-6965449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-7329312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2774708-841468
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-4932
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
342-5; discussion 346-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2774708-Animals,
pubmed-meshheading:2774708-Endotoxins,
pubmed-meshheading:2774708-Feces,
pubmed-meshheading:2774708-Germ-Free Life,
pubmed-meshheading:2774708-Rats,
pubmed-meshheading:2774708-Rats, Inbred Strains,
pubmed-meshheading:2774708-Reference Values,
pubmed-meshheading:2774708-Sepsis,
pubmed-meshheading:2774708-Shock, Hemorrhagic,
pubmed-meshheading:2774708-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
Does the bacteremia observed in hemorrhagic shock have clinical significance? A study in germ-free animals.
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pubmed:affiliation |
Department of Surgery, New Jersey Medical School, Newark 07103.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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