Linked Life Data

277105

Source:http://linkedlifedata.com/resource/pubmed/id/277105

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-9-25
pubmed:abstractText
The oral toxicity of Tifemoxone, phenoxymethyl-6 tetrahydroxazine-1, 3 thione-2, a new potential antidepressant was studied during 6 months in rats at 30, 85 and 230 mg/kg/d and in beagle dogs at 10, 55 and 300 mg/kg/d. Thyroid hyperplasia and hypoactivity were observed in the rats and dogs plasma triiodothyronine, determined in dogs, was modified. A dose dependent hepatotoxic effect was observed in the rats and dogs. In dogs at low dose, one animal died after B.S.P. test. Water consumption and urinary volume increased, weight loss and anemia appeared at high doses in both rats and dogs. Hair loss was observed in rats and convulsions in dogs. In conclusion, Tifemoxone like tetrahydroxazine thione and some derivatives caused thyreotoxicity, hairlessness and increased in water comsumption and diuresis and in addition it had strong hepatotoxic effect especially in the dog.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-9750
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-33
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Hepato- and thyreotoxicity of tifemoxone.
pubmed:publicationType
Journal Article