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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-9-14
|
| pubmed:abstractText |
Tannin, a naturally occurring polyphenolic compound, was found to inhibit the activity of purified poly(ADP-ribose) glycohydrolase from human placenta. The inhibition was dose-dependent and half maximal with 2.8 micrograms/ml of tannin. The inhibitory effect of tannin was two and three orders of magnitude more than those of ADP-ribose and cAMP, respectively. Kinetic analysis revealed that the inhibition by tannin was competitive with respect to the substrate poly(ADP-ribose).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0158-5231
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
701-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2764971-Binding, Competitive,
pubmed-meshheading:2764971-Binding Sites,
pubmed-meshheading:2764971-Female,
pubmed-meshheading:2764971-Glycoside Hydrolases,
pubmed-meshheading:2764971-Humans,
pubmed-meshheading:2764971-Kinetics,
pubmed-meshheading:2764971-Placenta,
pubmed-meshheading:2764971-Pregnancy,
pubmed-meshheading:2764971-Tannins
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Inhibitory effect of tannin on poly(ADP-ribose) glycohydrolase from human placenta.
|
| pubmed:affiliation |
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
|
| pubmed:publicationType |
Journal Article
|