Linked Life Data

2755509

Source:http://linkedlifedata.com/resource/pubmed/id/2755509

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6233
pubmed:dateCreated
1989-9-7
pubmed:abstractText
Mechanical stimulation of the body surface of the leech causes a localized withdrawal from dorsal, ventral and lateral stimuli. The pathways from sensory to motor neurons in the reflex include at least one interneuron. We have identified a subset of interneurons contributing to the reflex by intracellular recording, and our analysis of interneuron input and output connections suggests a network in which most interneurons respond to more than one sensory input, most have effects on all motor neurons and in which each form of the behaviour is produced by appropriate and inappropriate effects of many interneurons. To determine whether interneurons of this type can account for the behaviour, or whether additional types are required, model networks were trained by back-propagation to reproduce the physiologically determined input-output function of the reflex. Quantitative comparisons of model and actual connection strengths show that model interneurons are similar to real ones. Consequently, the identified subset of interneurons could control local bending as part of a distributed processing network in which each form of the behaviour is produced by the appropriate and inappropriate effects of many interneurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
340
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
468-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Function of identified interneurons in the leech elucidated using neural networks trained by back-propagation.
pubmed:affiliation
Department of Biology, University of California, San Diego, La Jolla 92093.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.