Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1989-8-28
|
pubmed:abstractText |
The halogenated pyrimidine 5-bromo-2'-deoxyuridine (BrdUrd) possesses both radiosensitizing and antimetabolite effects through its incorporation as a thymidine analog in replicating DNA. To evaluate the regional advantage for treatment of hepatic malignancy by hepatic arterial infusion, BrdUrd was infused into either the hepatic artery (HA) or a central vein (iv) in 26 rabbits with intrahepatic VX2 tumor. After a 24-hr constant rate infusion of 10, 20, or 40 mg/kg/24 hr, the percentage BrdUrd incorporation into the DNA of bone marrow, duodenal mucosa, liver, and hepatic VX2 tumor was measured by gas chromatography/mass spectrometry methods. VX2 tumor BrdUrd incorporation was greater by HA than by iv routes (P less than 0.001). At doses of 10 and 20 mg/kg/day, HA to iv BrdUrd incorporation ratios for VX2 tumor significantly exceeded those for bone marrow and duodenum (P less than 0.05). At appropriate dose rates, hepatic arterial administration of BrdUrd provides a regional advantage for DNA BrdUrd incorporation in the rabbit intrahepatic VX2 tumor.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0022-4804
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
112-6
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2755115-Animals,
pubmed-meshheading:2755115-Bone Marrow,
pubmed-meshheading:2755115-Bromodeoxyuridine,
pubmed-meshheading:2755115-Carcinoma, Squamous Cell,
pubmed-meshheading:2755115-Chromatography, Gas,
pubmed-meshheading:2755115-DNA,
pubmed-meshheading:2755115-DNA, Neoplasm,
pubmed-meshheading:2755115-Duodenum,
pubmed-meshheading:2755115-Hepatic Artery,
pubmed-meshheading:2755115-Injections, Intra-Arterial,
pubmed-meshheading:2755115-Injections, Intravenous,
pubmed-meshheading:2755115-Intestinal Mucosa,
pubmed-meshheading:2755115-Liver,
pubmed-meshheading:2755115-Liver Neoplasms,
pubmed-meshheading:2755115-Mass Spectrometry,
pubmed-meshheading:2755115-Neoplasm Transplantation,
pubmed-meshheading:2755115-Rabbits,
pubmed-meshheading:2755115-Vena Cava, Superior
|
pubmed:year |
1989
|
pubmed:articleTitle |
5-Bromo-2'-deoxyuridine incorporation into DNA in hepatic VX2 tumor-bearing rabbits.
|
pubmed:affiliation |
Department of Surgery, University of Michigan Medical Center, Ann Arbor.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|