Linked Life Data

2753059

Source:http://linkedlifedata.com/resource/pubmed/id/2753059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-9-1
pubmed:abstractText
Several plant-derived drugs are used in medical oncology today. Since only a small part of the flora has been tested for any kind of bioactivity intensive further screening may be rewarding. Fifty-six plant extracts were studied attempting to explore the feasibility of an assay that screens cytotoxic, antiviral and virus-enhancing activities in the same test. We made use of the property of an avian influenza virus replicating in a human breast cancer cell line. During the first 3 days of the test the cytotoxicity of the extracts was evaluated by phase-contrast microscopy. From the 4th day on when viral cytopathogenic effect became manifest we were able to identify antiviral and virus-enhancing activity among some of those extracts not showing cytotoxicity during the first 3 days of incubation. Aqueous extracts from the fruits of 56 plant species belonging to 22 families were screened. Twelve species exhibited cytotoxic, eight antiviral, five virus-enhancing and 31 no activity. These results show that the replication of a myxovirus in a human tumor cell offers the possibility of screening cytotoxic, antiviral and virus-enhancing activity in the same assay.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0277-5379
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
987-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Anticancer activities as well as antiviral and virus-enhancing properties of aqueous fruit extracts from fifty-six European plant species.
pubmed:affiliation
Department of Medicine, University Hospital, Zürich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't