| pubmed-article:2751311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2751311 | lifeskim:mentions | umls-concept:C0011015 | lld:lifeskim |
| pubmed-article:2751311 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:2751311 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:2751311 | lifeskim:mentions | umls-concept:C0085752 | lld:lifeskim |
| pubmed-article:2751311 | lifeskim:mentions | umls-concept:C0597433 | lld:lifeskim |
| pubmed-article:2751311 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2751311 | pubmed:dateCreated | 1989-8-16 | lld:pubmed |
| pubmed-article:2751311 | pubmed:abstractText | Pulse radiolysis studies of the one-electron reduction of adriamycin have now been extended to daunomycin. The daunomycin semiquinone has a pKa for phenolic dissociation of 2.8 +/- 0.1. Measurement of the one-electron reduction potential using several redox references at pH values within the range pH 6 to 12 indicated no significant difference between the semiquinones of adriamycin and those of daunomycin. A value of E1(7) = -341 +/- 15 mV (vs NHE) fitted the complete set of data for both compounds, with a pKa of the NH+3 group of the sugar moiety of 9.2 +/- 0.1. Measurement of equilibria between the semiquinones and the parent quinones and their fully reduced products showed a maximum semiquinone stability around pH 9. At pH 7 the stability constant is 0.04 for both adriamycin and daunomycin. From the equilibrium and E1 data, the second one-electron and the two-electron reduction potentials have been calculated over the pH range 7 to 12. E2(7) is -260 +/- 15 mV and Em7 is -300 +/- 15 mV for both compounds. The pKa values for the reduced anthracyclines have been calculated from the equilibrium data in the approximate pH range 7-12 to be 8.1 +/- 0.1 and 9.0 +/- 0.2 for the first two hydroxy groups and the two possible combinations for the ionization of the sugar NH+3 groups, with the remaining two hydroxy groups ionizing above pH 14. | lld:pubmed |
| pubmed-article:2751311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2751311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2751311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2751311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2751311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2751311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2751311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2751311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2751311 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2751311 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:2751311 | pubmed:author | pubmed-author:SwallowA JAJ | lld:pubmed |
| pubmed-article:2751311 | pubmed:author | pubmed-author:LandE JEJ | lld:pubmed |
| pubmed-article:2751311 | pubmed:author | pubmed-author:MukherjeeTT | lld:pubmed |
| pubmed-article:2751311 | pubmed:author | pubmed-author:BruceJ MJM | lld:pubmed |
| pubmed-article:2751311 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2751311 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2751311 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:2751311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2751311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2751311 | pubmed:pagination | 450-8 | lld:pubmed |
| pubmed-article:2751311 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:meshHeading | pubmed-meshheading:2751311-... | lld:pubmed |
| pubmed-article:2751311 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2751311 | pubmed:articleTitle | One-electron reduction of adriamycin and daunomycin: short-term stability of the semiquinones. | lld:pubmed |
| pubmed-article:2751311 | pubmed:affiliation | Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, England. | lld:pubmed |
| pubmed-article:2751311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2751311 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
