Linked Life Data

2745263

Source:http://linkedlifedata.com/resource/pubmed/id/2745263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-8-25
pubmed:abstractText
A simple isocratic HPLC procedure was developed for the analysis of seven quinolones and their metabolites in clinical specimens. It is likely that this system can be used for the assay of many other quinolone compounds, but not for nalidixic acid and the ciprofloxacin metabolite sulpho-ciprofloxacin which appear to be adsorbed in the column. Sample preparation takes approximately 20 min, and HPLC analysis is completed within 15 min with a simple solvent system eluted on a reversed phase column. The procedure is rapid, sensitive and specific, and is a modification of an assay for chloramphenicol and beta-lactam antibiotics. This method is therefore particularly useful for clinical laboratories, since a single HPLC system can be used for assays of chloramphenicol, beta-lactams and quinolones.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
597-604
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Rapid HPLC assay of fluoroquinolones in clinical specimens.
pubmed:affiliation
Department of Microbiology, Chinese University of Hong Kong, Shatin, New Territories.
pubmed:publicationType
Journal Article