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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-8-18
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pubmed:abstractText |
1. Membrane potential changes and contractions were recorded from mesenteric arteries and veins of the guinea-pig, during perivascular nerve stimulation or application of noradrenaline or adenosine triphosphate (ATP). 2. After alpha-adrenoceptor blockade, noradrenaline activated low affinity adrenoceptors (gamma-adrenoceptors) causing depolarization and arterial contraction only in the presence of an inhibitor of catecholamine uptake. 3. Noradrenaline did not cause depolarization or contraction of the vein after alpha-adrenoceptor blockade even after catecholamine uptake was blocked. 4. Adenosine triphosphate caused depolarization and contraction of both arteries and veins. These responses were abolished by alpha-,beta-,methylene adenosine triphosphate (Me-ATP). 5. Me-ATP abolished rapid excitatory junction potentials (e.j.ps) caused by perivascular nerve stimulation of arteries but had no effect on arterial responses mediated by gamma-adrenoceptors. 6. In veins, perivascular nerve stimulation evoked slow e.j.ps which persisted in the presence of Me-ATP but were abolished after blockade of alpha-adrenoceptors. 7. The observations indicate that P2 purinoceptors are present on both mesenteric artery and vein whilst gamma-adrenoceptors are localized near the neuromuscular junction of the artery. However gamma-adrenoceptors do not appear to be directly involved in the generation of arterial e.j.ps.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-202698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-2845065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-2858233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-2865364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-2880627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3000499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3009780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3011173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3026537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-31477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3693598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3701653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3789179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-3814914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-4052724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-430416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-5348467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-5545218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6110462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6121909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6127405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6127406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6141830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6152212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6199538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6243746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6253872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6273547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6291682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-6308237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2743089-7277224
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
993-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2743089-Adenosine Triphosphate,
pubmed-meshheading:2743089-Animals,
pubmed-meshheading:2743089-Electrophysiology,
pubmed-meshheading:2743089-Female,
pubmed-meshheading:2743089-Guinea Pigs,
pubmed-meshheading:2743089-Male,
pubmed-meshheading:2743089-Membrane Potentials,
pubmed-meshheading:2743089-Mesenteric Arteries,
pubmed-meshheading:2743089-Mesenteric Veins,
pubmed-meshheading:2743089-Muscle, Smooth, Vascular,
pubmed-meshheading:2743089-Muscle Contraction,
pubmed-meshheading:2743089-Norepinephrine,
pubmed-meshheading:2743089-Receptors, Adrenergic,
pubmed-meshheading:2743089-Receptors, Purinergic,
pubmed-meshheading:2743089-Sympathetic Nervous System
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pubmed:year |
1989
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pubmed:articleTitle |
The distribution of gamma-adrenoceptors and P2 purinoceptors in mesenteric arteries and veins of the guinea-pig.
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pubmed:affiliation |
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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