Linked Life Data

2735652

Source:http://linkedlifedata.com/resource/pubmed/id/2735652

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-7-14
pubmed:abstractText
The IW32 and NN10 cell lines are erythroleukemic cell lines which secrete erythropoietin (epo) into the culture medium constitutively. IW32 cells have a rearranged and amplified epo gene in addition to the normal gene. NN10 cells contain only the normal epo gene. DNase I hypersensitivity studies suggested that, in IW32 cells, it is the rearranged gene which is transcriptionally active. Sequence analysis of the upstream region of the rearranged epo gene suggests that the rearrangement has served to introduce a transcriptionally active gene close to the epo gene. This juxtaposition may explain the transcriptional activation of the epo gene at the rearranged locus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
554
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-35
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Studies of the constitutive expression of the mouse erythropoietin gene.
pubmed:affiliation
University of Chicago, Department of Biochemistry and Molecular Biology, Illinois 60637.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.