Linked Life Data

2731974

Source:http://linkedlifedata.com/resource/pubmed/id/2731974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-4
pubmed:dateCreated
1989-7-18
pubmed:abstractText
A colon tissue-bound disease specific IgG (CCA-IgG) antibody can be eluted from the colonic tissue of patients with ulcerative colitis (UC). CCA-IgG recognizes an Mr 40,000 protein present in both normal and diseased colon. Using an anti-Mr 40,000 murine monoclonal antibody this protein has been localized exclusively in colonic epithelial cells mainly along the baso-lateral domains of plasma membrane. Non-colonic epithelial tissues from 12 different organs including small intestine did not react with the anti-Mr 40,000 monoclonal antibody. The Mr 40,000 protein is present in the RPMI-4788 colon cancer cells but not in HeLa. The antibody dependent cell-mediated cytolysis by UC sera against RPMI-4788 cells was inhibited by anti-Mr 40,000 polyclonal antibody. These findings suggest that CCA-IgG and the Mr 40,000 colonic epithelial protein are involved in an autoimmune reaction and may be important in the pathogenesis of UC.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0882-0139
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
459-72
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Ulcerative colitis: specific antibodies against a colonic epithelial Mr 40,000 protein.
pubmed:affiliation
Department of Gastroenterology & Hepatology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't