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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4905
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pubmed:dateCreated |
1989-6-16
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pubmed:abstractText |
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-9
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:2717946-Aminoglycosides,
pubmed-meshheading:2717946-Animals,
pubmed-meshheading:2717946-Anti-Bacterial Agents,
pubmed-meshheading:2717946-Antibiotics, Antineoplastic,
pubmed-meshheading:2717946-Base Sequence,
pubmed-meshheading:2717946-Benzoates,
pubmed-meshheading:2717946-Binding Sites,
pubmed-meshheading:2717946-Carbohydrates,
pubmed-meshheading:2717946-Cattle,
pubmed-meshheading:2717946-Computer Simulation,
pubmed-meshheading:2717946-DNA,
pubmed-meshheading:2717946-Enediynes,
pubmed-meshheading:2717946-Models, Molecular,
pubmed-meshheading:2717946-Molecular Structure,
pubmed-meshheading:2717946-Nucleic Acid Conformation,
pubmed-meshheading:2717946-Structure-Activity Relationship
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pubmed:year |
1989
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pubmed:articleTitle |
Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.
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pubmed:affiliation |
Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.
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pubmed:publicationType |
Journal Article
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