Linked Life Data

2717704

Source:http://linkedlifedata.com/resource/pubmed/id/2717704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-6-16
pubmed:abstractText
Isometric tension of Na+-withdrawal contractures, membrane potential and intracellular Na+ activity (aiNa) have been measured in vitro under conditions which modify the activity of the Na+-Ca2+ exchanger of dystrophic limb muscles of (dy2J/dy2J) C57 BL/6J mice. In dystrophic soleus (Sol) and extensor digitorum longus (EDL) muscles exposed to Na+-free medium, there was a decrease in aiNa associated with a hyperpolarization of the membrane and the generation of a transient contracture. By contrast, exposing normal or denervated EDL muscles to Na+-free solution induced no change in aiNa nor in the resting tension. This study shows that Na+-Ca2+ exchange is still present in dystrophic Sol muscle. However from thermodynamic considerations, it could be suggested that the higher resting aiNa compared with that in normal muscle, may decrease the efficacy of the exchange.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0144-8757
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Na+-Ca2+ exchange in limb muscles of dystrophic (C57 BL/6J dy2J/dy2J) mice.
pubmed:affiliation
Laboratory of General Physiology, E.N.V., University of Nantes, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't