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rdf:type |
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lifeskim:mentions |
umls-concept:C0002812,
umls-concept:C0008546,
umls-concept:C0012854,
umls-concept:C0079068,
umls-concept:C0086418,
umls-concept:C1514562,
umls-concept:C1705176,
umls-concept:C1705178,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
7
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pubmed:dateCreated |
1989-6-14
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|
pubmed:abstractText |
DNA restriction fragments located 5' to the human c-myc gene display anomalous electrophoretic mobility on polyacrylamide gels. Computer modeling of the c-myc flanking DNA suggests that the slow-moving DNA fragments spanning nucleotides -1690 to -1054 (relative to c-myc promoter P1) and -718 to -452 form large left handed superhelices or curved structures while the fast-moving DNA fragment spanning nucleotides -407 to +78 has an unusually straight structure. These analyses also predict a periodic array of localized regions of bending through the superhelical domains. Micrococcal nuclease digestion of isolated nuclei reveals that the slow-moving DNA fragments exist in an ordered chromatin structure stable to nuclease, whereas the digestion pattern of the fast-moving DNA fragment suggests a less ordered array of nucleosomes or a non-nucleosomal chromatin structure.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-16593261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-2416474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-2825181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-2832157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-2995831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3004744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3021537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3025662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3037316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3043195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3162306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3162550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3271434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3271482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3271483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3271528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3464006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3520340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3540310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3540591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3561514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3671091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3742596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3749879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3785376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3786134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3889654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3894934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3905255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3912515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3917119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3949785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-3960133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6096016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6214637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6266922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6323997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6327064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6384525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6400882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6774262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-6854650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717410-7063417
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2819-33
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:2717410-Base Sequence,
pubmed-meshheading:2717410-Chromatin,
pubmed-meshheading:2717410-DNA, Superhelical,
pubmed-meshheading:2717410-HeLa Cells,
pubmed-meshheading:2717410-Humans,
pubmed-meshheading:2717410-Models, Molecular,
pubmed-meshheading:2717410-Nucleic Acid Conformation,
pubmed-meshheading:2717410-Proto-Oncogenes,
pubmed-meshheading:2717410-Restriction Mapping,
pubmed-meshheading:2717410-Software
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pubmed:year |
1989
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pubmed:articleTitle |
DNA topology of the ordered chromatin domain 5' to the human c-myc gene.
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pubmed:affiliation |
Department of Biochemistry, Wright State University, Dayton, OH 45435.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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