Linked Life Data

2712548

Source:http://linkedlifedata.com/resource/pubmed/id/2712548

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-5-26
pubmed:abstractText
The effect of sucralfate on the bioavailability of norfloxacin after single 400-mg doses of norfloxacin was evaluated in eight healthy males. Subjects received each of the following treatments in random sequence: (i), norfloxacin, 400 mg alone; (ii) sucralfate, 1 g, concurrently with norfloxacin, 400 mg; and (iii) sucralfate, 1 g, followed by norfloxacin, 400 mg, 2 h later. One day before administration of treatments 2 and 3, 1 g of sucralfate was given at 7 a.m., 11 a.m., 5 p.m., and 10 p.m. Blood samples were collected immediately before the norfloxacin dose and at 0.25, 0.5, 0.75, 1.0, 1.5, 2, 3, 4, 6, 8, 12, and 24 h postdose. Urine was collected in divided intervals: from 0 to 12, from 12 to 24, and from 24 to 48 h. Norfloxacin concentrations in plasma and urine were determined by high-performance liquid chromatography. Mean area under the plasma concentration-versus-time curve extrapolated to infinity decreased significantly (P less than 0.001) after norfloxacin was given with and 2 h after sucralfate. The relative bioavailabilities were 1.8% when norfloxacin was taken with sucralfate and 56.6% when it was taken 2 h after sucralfate. After norfloxacin was given alone, the mean norfloxacin concentrations in urine collected during intervals of 0 to 12, 12 to 24, and 24 to 28 h were 118.9 +/- 72.3, 18.8 +/- 12.5, and 2.4 +/- 2.2 micrograms/ml, respectively. After norfloxacin was given with sucralfate, however, the mean norfloxacin concentrations in urine collected during the same time intervals were 6.8 +/- 4.7, 1.8 +/- 1.4, and 0 +/- 0 microgram/ml, respectively. Because of low pH and relatively high magnesium concentration in urine, susceptibilities of bacteria in urine are 8- to 32-fold lower than in broth. This fact, in combination with the reduced bioavailability of norfloxacin in the presence of sucralfate or antacids, is likely to result in treatment failure. The effect of sucralfate given after norfloxacin was not examined, nor was the effect of sucralfate given more than 2 h before norfloxacin. Administration or norfloxacin with sucralfate should therefore by avoided.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-2941261, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-3311572, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-3556122, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-3753671, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-3755052, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-3793953, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-3799579, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-44471, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-6220672, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-6548940, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-6798099, http://linkedlifedata.com/resource/pubmed/commentcorrection/2712548-6894571
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-102
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Sucralfate reduces the gastrointestinal absorption of norfloxacin.
pubmed:affiliation
Department of Pharmacy, State University of New York School of Pharmacy, Buffalo, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial