Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1989-10-24
pubmed:databankReference
pubmed:abstractText
Salmonella typhimurium is a facultative intracellular pathogen capable of surviving within host phagocytic cells. Salmonella strains carrying phoP mutations are avirulent, unable to survive in macrophages, and extremely sensitive to peptides having antimicrobial activity such as the host-derived defensins. We present here the DNA sequence of the phoP gene and show that the deduced amino acid sequence of phoP has extensive homology with the Escherichia coli transcriptional regulators PhoB and OmpR, which control the expression of loci in response to different environmental stimuli. The psiD locus, which is regulated by phosphate availability, was found to be under the control of the phoP gene product. Sequences homologous to phoP were found in several Gram-negative species and in the yeast Saccharomyces cerevisiae.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-1100846, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-192713, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2466048, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2537530, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2544889, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2563595, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2646710, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2908087, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2985470, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-2997120, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3009420, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3054125, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3070321, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3162770, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3316029, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3517593, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3523484, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3531171, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3531187, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3537313, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3550103, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3555840, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-374361, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3802195, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-3986213, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-4585292, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-4882017, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-6260957, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-6310323, http://linkedlifedata.com/resource/pubmed/commentcorrection/2674945-7108955
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7077-81
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Salmonella typhimurium phoP virulence gene is a transcriptional regulator.
pubmed:affiliation
Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't