Linked Life Data

2671200

Source:http://linkedlifedata.com/resource/pubmed/id/2671200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-10-3
pubmed:abstractText
The diabetic macroangiopathy of lower limbs in characterized by chronic hypoxia with several abnormalities of hemodynamic, microcirculatory, rheological and metabolic red cell parameters. This study, in a double blind test with placebo was carried out on 40 subjects: 20 normal subjects and 20 diabetic patients suffering from microangiopathy of lower limbs. Ten are treated by 45 mg iv per day of Vinburnin, the 10 others received a placebo. Before and after treatment, the following parameters were measured: arterial flow rate at rest and after hyperhemia, transcutaneous oxygen level (TCpO2), red cell deformability, plasma viscosity, fibrinogen, red cell 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP). In this study, we have proved several effects of Vinburnin on the microcirculatory and rheological parameters the most essential for the transport of oxygen. The significant improvement of TCpO2, of ATP and 2,3-DPG red cell levels, of plasma viscosity and red cell deformability, even though we have no haemodynamic changes, confirm the rheological effects of Vinburnin. These pharmacological properties prove the interest and the special position of Vinburnin in the treatment of vascular diseases with acute or chronic tissular hypoxia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0392-9590
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-61
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Pharmacoclinical study of the action of vinburnin versus placebo: study of the hemodynamic, microcirculatory and rheological effects in angiopathy of the lower limbs in diabetes mellitus.
pubmed:affiliation
Unité de Recherches d'Hémorhéologie Clinique, Centre Hospitalier de Nevers, Pougues les Eaux, France.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Controlled Clinical Trial