Linked Life Data

2665002

Source:http://linkedlifedata.com/resource/pubmed/id/2665002

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-25
pubmed:abstractText
Tularemia is caused by the facultative intracellular bacterium Francisella tularensis. Attenuated live vaccines, such as F. tularensis LVS (live vaccine strain), afford good--although not complete--protection; how to judge the degree of this protection has long been a problem. Both natural infection and vaccination result in immunospecific and long-lasting humoral and cell-mediated immunity. The latter is the crucial protective mechanism, whereas the humoral response protects only against strains of reduced virulence, such as those used in the vaccines. Immune serum has been used to screen for structures of F. tularensis with the ability to induce a protective immune response. This immune serum is, however, primarily directed toward antigens different from those involved in cell-mediated immunity. Serum antibodies from primed individuals recognize carbohydrate capsule antigens of F. tularensis, whereas T lymphocytes recognize membrane polypeptides of the organism. The preparation of membrane polypeptides from F. tularensis is now facilitated by the availability of a capsule-deficient mutant of F. tularensis LVS. In vitro, several membrane polypeptides of the mutant stimulate T lymphocytes from vaccinees and from naturally infected individuals. Further studies of the mechanisms of induction of protective immunity should focus on these membrane polypeptides.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0162-0886
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
440-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Nature of protective immunity to Francisella tularensis.
pubmed:affiliation
Department of Infectious Diseases, University of Umeå, Sweden.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't