Linked Life Data

2663855

Source:http://linkedlifedata.com/resource/pubmed/id/2663855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1989-8-18
pubmed:abstractText
Mutations in prfB, encoding release factor 2 (UGA- and UAA-specific), increase transcription termination at the trp operon attenuator in Escherichia coli strains grown in the presence of tryptophan. The prfB mutations have no effect on basal level expression in strains in which the natural trp leader peptide stop codon UGA was replaced by either UAG or UAA. The effect of introducing prfB mutations into mutant strains containing altered trp leader regions that influence basal level transcription readthrough was also determined. Our findings support a model for basal level control of trp operon expression in which ribosome release from the leader peptide stop codon, formation of alternative transcript secondary structures, and the position of the transcribing RNA polymerase regulate expression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12284-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Regulation of basal level expression of the tryptophan operon of Escherichia coli.
pubmed:affiliation
Department of Biological Sciences, Stanford University, California 94305-5020.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't