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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1977-6-30
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pubmed:abstractText |
beta-Endorphin is a 31 amino acid polypeptide isolated from the pituitary gland of different species of animals. It has strong morphine-like activity. It is formed of amino acid residues 61-91 of beta-lipotropin. Speculation has arisen whether it is biosynthesized in situ or transformed after secretion of beta-lipotropin. The present in vitro studies show that it is found as beta-endorphin in bovine pituitary slices incubated with radioactive amino acid precursor [35S]methionine. Chemical characterization and microsequencing of the newly biosynthesized material proves its identity with isolated unlabeled beta-endorphin and shows that it has a methionine residue at its fifth position, as expected.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1063395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1064855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1064883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1148190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-11882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1207728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1264258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-1276982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-14491328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-4162144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-4192532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-4366173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-4370934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-5657063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-6035976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-817843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-837244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-843377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-955087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-985493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/266182-999687
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1403-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1977
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pubmed:articleTitle |
In vitro biosynthesis of beta-endorphin in pituitary glands.
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pubmed:publicationType |
Journal Article,
In Vitro
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