Linked Life Data

2641921

Source:http://linkedlifedata.com/resource/pubmed/id/2641921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-10-15
pubmed:abstractText
We have studied the influence of chronic infusions of antibodies against Ia antigen into the CSF on immunological reactions to intraventricular xenografts in rats. The antibodies were infused with osmotic pumps implanted one day before grafting. One set of control groups consisted of animals with xenografts which simultaneously received antibody against penicillin or vehicle with no antibody. In a second set of control groups, antibodies against Ia antigen, penicillin, rat anti-mouse IgG or vehicle (no antibody) were administered alone, without grafts. In the animals that received infusions of antibodies against either Ia antigen or penicillin plus xenografts, intense granulomatosis reactions were observed in the host brains. These reactions were not observed in the animals that received antibody infusions without xenografts. It appears that this reaction was produced by the massive and persistent injection of immunoglobulins, together with the presence of xenograft tissue. The chronic infusion of Ia antibodies did not prolong xenograft survival.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0896-0623
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-202
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Intraventricular xenografts: chronic injection of antibodies into the CSF provokes granulomatosis reactions but Ia antibodies do not enhance graft survival.
pubmed:affiliation
National Institute of Mental Health, Neurosciences Center at St. Elizabeths, Washington, DC 20032.
pubmed:publicationType
Journal Article