Linked Life Data

2629895

Source:http://linkedlifedata.com/resource/pubmed/id/2629895

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-5-1
pubmed:abstractText
Six hours after glycerol (G) injection in normal rats (NR), creatinine clearance (Ccr) decreased while urinary TXB2 (TXA2), 6-keto-PGF1 alpha (PGI2) and PGE2 significantly increased. The administration of OKY-046, a selective TXA-synthase inhibitor in glycerol-treated rats (GTR), significantly prevented the decrease in Ccr (indicating a partial protection against the development of acute renal failure) (ARF) and the increase in urinary TXA2 excretion, while it did not significantly alter urinary prostaglandin (PG) excretion. However, although TXB2 synthesis by the isolated glomeruli (IG) obtained from rats sacrificed 2 and 6 h after G injection was significantly enhanced, PGE2 and 6-keto-PGF1 alpha (6kPGF1 alpha) synthesis was augmented only by the IG obtained from rats killed 6 h after G administration. TXB2 and 6kPGF1 alpha synthesis by the IG obtained from rats killed 24 h after G injection returned to normal levels, while PGE2 synthesis continued to be elevated. Thus the enhanced release of PGE2 and 6kPGF1 alpha observed in intact animals in the early phase of ARF must be of medullary origin, while the augmented release of TXB2 (TXA2) by the IG must be responsible for the afferent arteriolar contraction during the early phase of this syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0934-9820
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-61
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The role of prostaglandin and thromboxane synthesis by the glomeruli in the development of acute renal failure.
pubmed:affiliation
Renal and Vascular Pathology, Broussais Hospital, Paris, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't