Linked Life Data

2625133

Source:http://linkedlifedata.com/resource/pubmed/id/2625133

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1990-4-12
pubmed:abstractText
A brain dialysis technique was used to investigate the effects of cholinergic drugs on acetylcholine (ACh) release and on the extracellular choline levels. Scopolamine (0.5 mg/kg s.c.) markedly increased ACh release in frontal cortex, hippocampus and corpus striatum. Conversely, it significantly decreased choline levels in extracellular spaces of these three regions. Oxotremorine (0.5 mg/kg i.p.) induced no significant ACh release in these three regions, probably due to the presence of highly concentrated physostigmine in the perfusate, while it induced an increase of the choline levels in both frontal cortex and hippocampus but not in corpus striatum. Nicotine (0.5 mg/kg s.c.) significantly increased the ACh release in these three regions with no change in choline levels. Nicotine had a biphasic effect on ACh release in frontal cortex and hippocampus but not in corpus striatum. It should be noted that all such cholinergic drugs, in our time course determinations, yielded certain differences among these brain regions for both the magnitude and the response pattern of ACh and choline levels. The present investigation appears to indicate that the in vivo brain dialysis technique can be useful for probing cholinergic neurotransmission of cholinergic drugs via presynaptic terminals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-41
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis.
pubmed:affiliation
Section of Pharmacology, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
pubmed:publicationType
Journal Article