Linked Life Data

2624114

Source:http://linkedlifedata.com/resource/pubmed/id/2624114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-3-20
pubmed:abstractText
Sophoramine (SA) exerted an inhibitory effect on arrhythmias in rats induced by aconitine and coronary artery ligation, and elevated the ventricular fibrillation threshold to electrical stimulation in rabbits. SA 98 mumol/L decreased the speed-up effect of isoprenaline on spontaneous beating in rabbit isolated atria, with the dose-effect curve being shifted to the right and the maximal effect being inhibited. SA 250 mumol/L enhanced the contractile force of the isolated rabbit atria, but had no effect on the contractions of rabbit aorta strips induced by high K+ and norepinephrine. In isolated guinea pig ventricular papillary muscle, SA 25-100 mumol/L greatly prolonged the action potential duration (APD) and effective refractory period (ERP). SA 75 mumol/L prolonged the APD of rabbit sinoatrial node cells and reduced the spontaneous excitatory frequency (SEF).
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Anti-arrhythmic mechanisms of sophoramine].
pubmed:publicationType
Journal Article, English Abstract