Linked Life Data

2617216

Source:http://linkedlifedata.com/resource/pubmed/id/2617216

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-3-5
pubmed:abstractText
Capsaicin causes release and long-term depletion of neuropeptides from sensory neurons. Recently, critical rat pedicle flaps pretreated with capsaicin have shown decreased survival. In the present study, the effect of systemic capsaicin pretreatment on the no-reflow phenomenon was investigated in the rat. Effective depletion of neuropeptides was confirmed with functional tests and immunohistochemistry. Groin island flaps were exposed to 4, 6, 8, 10 or 12 hours of warm ischemia, and flap survival was judged one week postoperatively. In contrast to previously reported negative effects on pedicle flap survival after pretreatment with capsaicin, the present study showed no difference in flap survival between capsaicin-pretreated rats and controls. It is concluded that depletion of neuropeptides from sensory neurons does not have negative effects on the tissue's ability to withstand prolonged complete ischemia. As this contrasts with the findings in critical pedicle flaps, the influence of sensory neuropeptides and the necrosis mechanisms are likely to be different in these two types of ischemic conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0284-4311
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Sensory denervation with capsaicin does not influence the critical ischemia time in rat island flaps.
pubmed:affiliation
Department of Plastic Surgery, Karolinska Hospital, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't