Linked Life Data

2611671

Source:http://linkedlifedata.com/resource/pubmed/id/2611671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-3-1
pubmed:abstractText
The question whether chronic membrane depolarization regulates selectively the expression of different muscarinic cholinergic receptors has been studied in primary neuronal cultures prepared from two regions of embryonic rat brain. Chronic (3 or 6 days) but not acute (3 or 24 h) membrane depolarization of cultured septal neurons with 40 mM potassium chloride have increased the number of muscarinic receptors by 168 +/- 28%, but no such effect has been observed with hippocampal cultures. Displacement experiments with the M1 selective antagonist pirenzepine have shown that muscarinic receptors in the septum of adult rat have 3-5 times lower affinity to this compound than hippocampus receptors. The results suggest that chronic membrane depolarization selectively increases the number of presynaptic muscarinic receptors, expressed by septal neurons, whereas hippocampal neurons expressing postsynaptic receptors have no such response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
505
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-2
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Selective regulation of different muscarinic receptors in septum and hippocampus neuronal cultures.
pubmed:affiliation
Department of Genetics, Weizmann Institute of Science, Rehovot, Israel.
pubmed:publicationType
Journal Article